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In cooperation with the University Hospital Schleswig-Holstein in Kiel, the GEOMAR - Helmholz Centre, Prof. Eisenhauer and osteolabs GmbH in Kiel and the company CRC Kiel, clinical studies OSTEOGEO (100 postmenopausal women) and "Peak Bone" (30 healthy premenopausal women) were carried out. With a sensitivity of 100%, all osteoporosis patients were detected by means of calcium isotope markers (CIM). As expected, additional osteoporotic women were found (specificity 55%). This can be explained by the detection of calcium loss already in earlier stages and the observation of the entire skeleton.